Immunoregulation and Resistance to Aquatic Pathogens with Dietary Nucleotides in Pacific White Shrimp, Litopenaeus vannamei

Using vegetable protein sources as a replacement for fish meal (FM) in the diet of Pacific white shrimp (PWS) has negative impact on their health. Acute hepatopancreatic necrosis disease (AHPND), caused by Vibrio parahaemolyticus, affects PWS and causes financial losses. Nucleotides modulate immune response could contribute to counteracting these issues. Our objective was evaluate effects nucleotide supplementation performance, response, survival when challenged with V. receiving FM partially replaced sources. A feeding trial (1000 PWS; 56 days) challenge (600 10 were performed using diets different inclusion levels (26%, 23.4%, 22.1%, 20.8%), or without 0.1% nucleotides. non-challenged, non-supplemented group also used trial. Adding nucleotides reduced allowed significantly better results growth performance parameters total hemocyte count (THC). In trial, compared control, led higher THC rate 15 h post-challenge. conclusion, adding improves resistance aquatic pathogens, allowing be negatively affecting performance.